化学化工学院
吴相华
有机化学专业，副教授，硕士生导师
联系方式：chxhwu@sina.com
学术任职及兼职
无
主要研究方向
功能有机小分子荧光染料的构建及生物应用
主要招生专业
有机化学
教育与工作经历:
2000年9月～2004年7月，江西师范大学化学教育，学士
2004年7月～2009年12月，华中师范大学有机化学，博士研究生
2010年1月～2011年8月，云南师范大学化工学院，讲师
2011年9月～现在，云南师范大学化工学院，副教授
获奖成果和荣誉称号：
1. 张俊峰，吴相华，刘波. 高选择性识别生物小分子荧光/电化学传感器构建及其机制研究，云南省科学技术奖(自然科学类) 三等奖，2020年
主持科研项目
1. 国家自然科学基金项目（青年基金项目），具有离子识别功能的共轭双金属配合物研究，执行时间：2011/01-2013/12
2. 云南省基础研究计划项目（面上项目），功能双金属配合物在电化学传感器中的应用研究，执行时间：2010/10-2013/9
3.云南省基础研究计划项目（面上项目），功能化炔金(I)配合物的合成及其抗肿瘤活性研究，执行时间：2020/09-2023/08
代表性著作、论文、专利等
1. Mingrui Zhang, Lingyu Jin, Yuda Zhu, Junfeng Kou, Bo Liu, Jing Chen, Xiaolin Zhong, Xianghua Wu*, Junfeng Zhang*, Wenxiu Ren* A near-infrared II fluorescent dye based on oxanthracene: Real-time imaging of drug-induced acute liver injury and photothermal therapy for tumor. Chinese Chemical Letters, 2025, 36(10), 110772.
2. Junfeng Zhang, Lingyu Jin, Bin Xiao, Dongeun Kim, Siwei Hua, Yangmei Hua, Yangjie Liu, Xuefei Huang, Junfeng Kou*, Bo Liu, Xianghua Wu, Xiaolin Zhong, Amit Sharma, Yuda Zhu*, Wen Xiu Ren*, and Jong Seung Kim* NIR-Responsive Xanthene Probes for Dual-Mode Cancer Treatment and Bioimaging. Anal. Chem., 2025, 97(36), 19597–19605.
3. Fengying Yuan, Qiao Zhao, Yanyan Zeng, Xu Fang Liao, Jiali Li, Bo Liu, Jun Feng Kou, Xiaolin Zhong, Xiang Hua Wu,* Jun Feng Zhang* and Wen Xiu Ren* A COX2-targeting cancer-specific fluorescent probe for hydrogen sulfide detection in living cells, Caenorhabditis elegans, and zebrafish. Analyst, 2024, 149(5), 1489–1495.
4. Qiu Mei Chen, Yanyan Zeng, Ming Rui Zhang, Lingyu Jin, Ping Zhou, Xiang Hua Wu*, and Wen Xiu Renb,* Synthesis and antitumor activity of gold(I) N-heterocyclic carbene with dithiocarbamate and alkynyl complexes. Inorganica Chimica Acta, 2024, 568, 122085.
5. Qiao Zhao, Fengying Yuan, Bin Xiao, Yanyan Zeng, Junfeng Kou,* Bo Liu, Xiaoqing Mou, Xianghua Wu, June Seok Heo, Xiaolin Zhong, Junfeng Zhang,* and Wen Xiu Ren* A lysosome-targeted dual-responsive fluorescent probe for simultaneous detection of NO and H2S in living cells, wild-type C. elegans and zebrafish. Dyes and Pigments, 2024, 228, 112224.
6. Yu Min Wang, Jiali Li, Jian Hua Chen, Bo Liu, Yanyan Zeng, Ja-Yun Lim, Ya Ting Liu, Jun Feng Zhang*, Xiang Hua Wu*, and Wen Xiu Ren* A dual-responsive fluorescent probe for detection of H2O2 and HClO in living cells and Caenorhabditis elegans. Dyes and Pigments, 2023, 215, 111218.
7. Yu Chen, YuminWang, Xiang HuaWu*, Bo Liu*, Jun FengZhang* Discriminative detection of cysteine/homocysteine and glutathione in HeLa cells by dual-channel fluorescent probe. Dyes and Pigments, 2021, 186, 109015.
8. Xianghua Wu, Yuxun Lu, Bo Liu, Yu Chen, Junfeng Zhang*, Ying Zhou* A H2S-triggered two-photon ratiometric fluorescent theranostic prodrug for bio-imaging. Chinese Chemical Letters, 2021, 32, 2380–2384.
9. Qiu Mei Chen, Yi Chen, Xiang Hua Wu* Synthesis and antitumor activity of a novel alkynyl (phosphine) digold(I) complexes. Transition Metal Chemistry, 2021, 46(7), 495–501.
10. Yu Chen, Ja-Yun Lim, Xiang Hua Wu, June Seok Heo, FengyingYuan, Jun Feng Zhang*, Dae Wui Yoon*, Wen Xiu Ren* Development of H2S and HClO dual-responsive fluorescent probe for cancer recognition. Dyes and Pigments, 2021, 195, 109666.
11. Yu Chen, Keying Bi, RuiTing Hao, Ping Xie, Lina Huang, Yumin Wang, JunFeng Zhang,,* Rui Xu,* and XiangHua Wu* A near-infrared ratiometric fluorescent probe for detection of peroxynitrite in HeLa cells based on a dicyanometh-ylene-4H-pyran coumarin system. Chinese Journal of Organic Chemistry, 2020, 40(2), 511–515.
12. Yu Chen, Yu Qiang Zhao, Ping Xie, Lina Huang, Yumin Wang, Jun Feng Zhang,* Xiang Hua Wu,* Ying Zhou* Near-infrared fluorescent probes for detection of exogenous and endogenous hypochlorite in living cells. Dyes and Pigments, 2020, 177, 108308.
13. 吴相华，张俊峰，刘波，王玉敏，专利名称：一种荧光探针分子及其制备方法与应用，发明专利，专利授权号：ZL 202110566718.7，专利授权日期：2022/06/07
14. 吴相华，张俊峰，寇军锋，刘波，肖彬，专利名称：一种苯并吡喃鎓荧光染料分子、制备方法及应用，发明专利，专利授权号：ZL 2024 1 1311928.1，专利授权日期：2025/05/30
15. 寇军锋，刘波，吴相华，张俊峰，王春梅，专利名称：一种D-π-A型半花菁染料、制备方法及应用，专利号：ZL 2024 1 1307238.9，专利授权日期：2025/05/30
16. 刘波，寇军锋，张俊峰，吴相华，王春梅，专利名称：一种类香豆素半花菁荧光染料分子、制备方法及应用，专利号：ZL2024 11313190.2，专利授权日期：2025/06/19
教学方面
主讲课程
本科生课程《有机化学》，《有机化学实验》
研究生课程《金属有机化学》